{"product_id":"mapk8ip1-polyclonal-antibody-e-ab-92930","title":"MAPK8IP1 Polyclonal Antibody - E-AB-92930","description":"\u003cp\u003eMAPK8IP1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-92930-60, E-AB-92930-120, E-AB-92930-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: MAPK8IP1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: MAPK8IP1; IB1; JIP-1; JIP1; PRKM8IP\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q9UQF2\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human MAPK8IP1\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:200-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 77kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 78kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146664804531,"sku":"E-AB-92930-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146664837299,"sku":"E-AB-92930-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146664870067,"sku":"E-AB-92930-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_d9df473d-a7da-4d8f-b9d7-4216b6f1ee43.png?v=1710299692","url":"https:\/\/afsbio.com\/products\/mapk8ip1-polyclonal-antibody-e-ab-92930","provider":"AFSBio Inc.","version":"1.0","type":"link"}