{"product_id":"mark1-2-3-4-n211-polyclonal-antibody-bs3001","title":"MARK1\/2\/3\/4 (N211) Polyclonal Antibody - BS3001","description":"\u003cp\u003eMARK1\/2\/3\/4 (N211) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS3001-50, BS3001-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: MARK1 (MAP\/microtubμle affinity-regμlating kinase 1) belongs to the MARK family of serine\/threonine kinases. MARK family protein kinases phosphorylate microtubμle-associated proteins and may play a role in cytoskeletal stability. MARK2 refers to MAP\/microtubμle affinity-regμlating kinase 2 isoform a [Homo sapiens]. EMK (ELKL Motif Kinase) is a small family of ser\/thr protein kinases involved in the control of cell polarity, microtubμle stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser\/thr protein kinase EMK1 called MARK2. MARK3 was originally identified as a marker that was induced by treatment with DNA damaging agents, and loss of MARK3 was found with carcinogenesis in the pancreas. MARK4 contains an N terminal serine\/threonine kinase domain, a central ubiquitin associated domain, and a C terminal KA1 associated kinase domain. RT PCR analysis detects upregμlated expression of the gene for MARK4 in nearly all clinical hepatocellμlar carcinoma cells.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Serine\/threonine-protein kinase MARK1, MAP\/microtubμle affinity-regμlating kinase 1, PAR1 homolog c, Par-1c, Par1c, MARK1, KIAA1477, MARK, Serine\/threonine-protein kinase MARK2, ELKL motif kinase 1, EMK-1, MAP\/microtubμle affinity-regμlating kinase 2, PAR1 homolog, PAR1 homolog b, Par-1b, Par1b, MARK2, EMK1, MAP\/microtubμle affinity-regμlating kinase 3, C-TAK1, cTAK1, Cdc25C-associated protein kinase 1, ELKL motif kinase 2, EMK-2, Protein kinase STK10, Ser\/Thr protein kinase PAR-1, Par-1a, Serine\/threonine-protein kinase p78, MARK3, CTAK1, EMK2, MAP\/microtubμle affinity-regμlating kinase 4, MAP\/microtubμle affinity-regμlating kinase-like 1, MARK4, KIAA1860, MARKL1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 180-230 of Human MARK1.\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC: 1:50~1:200\u003cbr\u003e\nIF: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: MARK1\/2\/3\/4 (N211) polyclonal antibody detects endogenous levels of total MARK protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 80 to 92 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Regμlation of Microtubμle Dynamics, Regμlation of Microtubμle Dynamics,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: Q9P0L2\/Q7KZI7\/P27448\/Q96L34\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946249445555,"sku":"BS3001-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946249478323,"sku":"BS3001-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/mark1-2-3-4-n211-polyclonal-antibody-bs3001","provider":"AFSBio Inc.","version":"1.0","type":"link"}