{"product_id":"mark2-rabbit-polyclonal-antibody-es2747","title":"MARK2 Rabbit Polyclonal Antibody - ES2747","description":"\u003cp\u003eMARK2 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES2747-50, ES2747-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: microtubule affinity regulating kinase 2(MARK2) Homo sapiens This gene encodes a member of the Par-1 family of serine\/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, Monkey\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: MARK2, EMK1, Serine\/threonine-protein kinase MARK2, ELKL motif kinase 1, EMK-1, MAP\/microtubule affinity-regulating kinase 2, PAR1 homolog, PAR1 homolog b, Par-1b, Par1b\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human MARK2. AA range:10-59\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: MARK2\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: MARK2 Polyclonal Antibody detects endogenous levels of MARK2 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 85kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: ATP + a protein = ADP + a phosphoprotein\u003cbr\u003e\nCofactor: Magnesium\u003cbr\u003e\nEnzyme Regulation: Activated by phosphorylation on Thr-208 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39\u003cbr\u003e\nFunction: Role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection\u003cbr\u003e\nSimilarity: Belongs to the protein kinase superfamily\u003cbr\u003e\nSimilarity: Belongs to the protein kinase superfamily. CAMK Ser\/Thr protein kinase family. MARK subfamily\u003cbr\u003e\nSimilarity: Contains 1 KA1 (kinase-associated) domain\u003cbr\u003e\nSimilarity: Contains 1 protein kinase domain\u003cbr\u003e\nSimilarity: Contains 1 UBA doma\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell membrane, Peripheral membrane protein Cytoplasm Lateral cell membrane Cytoplasm, cytoskeleton Cell projection, dendrite Cytoplasm Phosphorylation at Thr-596 by PRKCZ\/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relocation from the cell membrane to the cytoplasm\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: MARK2\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Serine\/threonine-protein kinase MARK2\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 13728\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q05512\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 60328\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: O08679\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314228908211,"sku":"ES2747-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314228940979,"sku":"ES2747-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/mark2-rabbit-polyclonal-antibody-es2747","provider":"AFSBio Inc.","version":"1.0","type":"link"}