{"product_id":"mark4-rabbit-polyclonal-antibody-es6934","title":"MARK4 Rabbit Polyclonal Antibody - ES6934","description":"\u003cp\u003eMARK4 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES6934-50, ES6934-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: microtubule affinity regulating kinase 4(MARK4) Homo sapiens This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: MARK4, KIAA1860, MARKL1, MAP\/microtubule affinity-regulating kinase 4, MAP\/microtubule affinity-regulating kinase-like 1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human MARK4. AA range:461-510\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: MARK4\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: MARK4 Polyclonal Antibody detects endogenous levels of MARK4 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Ubiquitous, Isoform 2 is brain-specific (PubMed:11326310), Expressed at highest levels in brain and testis, Also expressed in heart, lung, liver, muscle, kidney and spleen (PubMed:14594945),\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 83kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: ATP + a protein = ADP + a phosphoprotein\u003cbr\u003e\nSimilarity: Belongs to the protein kinase superfamily. CAMK Ser\/Thr protein kinase family. MARK subfamily\u003cbr\u003e\nSimilarity: Contains 1 KA1 (kinase-associated) domain\u003cbr\u003e\nSimilarity: Contains 1 protein kinase domain\u003cbr\u003e\nSimilarity: Contains 1 UBA domain\u003cbr\u003e\nTissue Specificity: Ubiquitous. Isoform 2 is brain-specific\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm Cell projection, dendrite Localized at the tips of neurite-like processes in differentiated neuroblast cells Detected in the cytoplasm and neuropil of the hippocampus\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: MARK4\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: MAP\/microtubule affinity-regulating kinase 4\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 232944\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q8CIP4\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313662054579,"sku":"ES6934-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313662087347,"sku":"ES6934-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/mark4-rabbit-polyclonal-antibody-es6934","provider":"AFSBio Inc.","version":"1.0","type":"link"}