{"product_id":"mbd3-polyclonal-antibody-bt-ap05256","title":"MBD3 Polyclonal Antibody - BT-AP05256","description":"\u003cp\u003eMBD3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP05256-20, BT-AP05256-50, BT-AP05256-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MBD3 belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). Methyl-CpG-binding domain protein 3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MBD3\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: MBD3 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 32844\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: O95983; Mouse: Q9Z2D8\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: MBD3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 53615; Mouse: 17192\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239680991411,"sku":"BT-AP05256-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239681024179,"sku":"BT-AP05256-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239681056947,"sku":"BT-AP05256-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_d9c888c0-a72b-4013-aaa4-05add2e0652f.png?v=1769397925","url":"https:\/\/afsbio.com\/products\/mbd3-polyclonal-antibody-bt-ap05256","provider":"AFSBio Inc.","version":"1.0","type":"link"}