{"product_id":"mbnl1-polyclonal-antibody-e-ab-62123","title":"MBNL1 Polyclonal Antibody - E-AB-62123","description":"\u003cp\u003eMBNL1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-62123-60, E-AB-62123-120, E-AB-62123-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: MBNL1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: MBNL1; EXP; MBNL\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q9NR56\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and\/or splicing activities.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human MBNL1 (NP_066368.2).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:500-1:2000   IHC \t1:50-1:200   IF \t1:50-1:100\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 33kDa\/34kDa\/36kDa\/37kDa\/39kDa\/40kDa\/41kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 42kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146227056819,"sku":"E-AB-62123-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146227089587,"sku":"E-AB-62123-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146227122355,"sku":"E-AB-62123-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_8965bd48-af33-4343-a40d-6d9ddcddb060.png?v=1710291973","url":"https:\/\/afsbio.com\/products\/mbnl1-polyclonal-antibody-e-ab-62123","provider":"AFSBio Inc.","version":"1.0","type":"link"}