{"product_id":"mcm3-polyclonal-antibody-e-ab-40230","title":"MCM3 Polyclonal Antibody - E-AB-40230","description":"\u003cp\u003eMCM3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-40230-60, E-AB-40230-120, E-AB-40230-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: MCM3\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Cervical cancer proto oncogene 5; DNA polymerase alpha holoenzyme associated P1; HCC 5; HCC5; hRlf beta subunit; Human cervical cancer proto oncogene 5; MCM 3; MGC1157; Minichromosome maintenance complex component 3; P1 h; P1 MCM3; P1.h; p102; Replication licensing factor beta subunit; \u003cbr\u003e\nRLF beta subunit; RLFB\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P25205\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with mCM5\/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 2mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant Human DNA replication licensing factor MCM3 protein\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen Affinity Purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:1000  IHC 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 91,96 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 100 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146023829683,"sku":"E-AB-40230-60","price":175.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146023862451,"sku":"E-AB-40230-120","price":322.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146023895219,"sku":"E-AB-40230-200","price":532.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_31afd0f1-2ab0-48f6-a6b8-1368eaba5c9c.png?v=1710290020","url":"https:\/\/afsbio.com\/products\/mcm3-polyclonal-antibody-e-ab-40230","provider":"AFSBio Inc.","version":"1.0","type":"link"}