{"product_id":"mcm4-phospho-ser54-polyclonal-antibody-ra27091","title":"MCM4 (phospho Ser54) Polyclonal Antibody - RA27091","description":"\u003cp\u003eMCM4 (phospho Ser54) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA27091-50, RA27091-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: minichromosome maintenance complex component 4 (MCM4) Homo sapiens The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC\/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcri\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: MCM4; CDC21; DNA replication licensing factor MCM4; CDC21 homolog; P1-CDC21\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC-p; IF (paraffin section) ; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Monkey\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 4173\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 85\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P33991\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121389625523,"sku":"RA27091-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121389658291,"sku":"RA27091-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_a010bca8-8f03-4735-aebe-de0d92d02229.png?v=1773347148","url":"https:\/\/afsbio.com\/products\/mcm4-phospho-ser54-polyclonal-antibody-ra27091","provider":"AFSBio Inc.","version":"1.0","type":"link"}