{"product_id":"mcm6-polyclonal-antibody-e-ab-14210","title":"MCM6 Polyclonal Antibody - E-AB-14210","description":"\u003cp\u003eMCM6 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-14210-60, E-AB-14210-120, E-AB-14210-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: MCM6\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: DNA replication licensing factor MCM6; MCG40308; Mcm6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog; S. pombe); MCM6 minichromosome maintenance deficient 6; MCM6; Minichromosome maintenance complex component 6; Minichromosome maintenance deficient (mis5 S. pombe) 6; Minichromosome maintenance deficient 6 homolog; Minichromosome maintenance protein 6; Mis5; MIS5 homolog; p105MCM\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q14566\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.8 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein of human MCM6\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IHC 1:100-1:300\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 93kDa\u003c\/p\u003e\n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43136365854899,"sku":"E-AB-14210-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43136365887667,"sku":"E-AB-14210-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43136365920435,"sku":"E-AB-14210-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_445ab5ff-1b6b-4dc2-9b96-3ba93996b251.png?v=1709989428","url":"https:\/\/afsbio.com\/products\/mcm6-polyclonal-antibody-e-ab-14210","provider":"AFSBio Inc.","version":"1.0","type":"link"}