{"product_id":"mcm7-polyclonal-antibody-e-ab-40231","title":"MCM7 Polyclonal Antibody - E-AB-40231","description":"\u003cp\u003eMCM7 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-40231-60, E-AB-40231-120, E-AB-40231-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: MCM7\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CDABP0042; CDC 47; CDC47; CDC47 homolog; Cdc47; S. cerevisiae; homolog of; DNA replication licensing factor MCM7; Homolog of S. cerevisiae Cdc47; MCM 2; MCM 7; MCM2; MCM2; formerly; Mcm7; MCM7 minichromosome maintenance deficient 7; MCM7_HUMAN; Minichromosome Maintainence 7; Minichromosome maintainence; S. cerevisiae; homolog of; Minichromosome maintenance complex component 7; Minichromosome maintenance deficient 7; Minichromosome maintenance protein 7; P1.1 MCM3; P1.1-MCM3; P1CDC47; P85MCM; PNAS 146; PNAS146; PPP1R104; Protein phosphatase 1; regulatory subunit 104\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P33993\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1\/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 2 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant Human DNA replication licensing factor MCM7 protien\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:50-1:200\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43133432955059,"sku":"E-AB-40231-60","price":175.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43133432987827,"sku":"E-AB-40231-120","price":322.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43133433020595,"sku":"E-AB-40231-200","price":532.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_05f6c02b-9c53-4e20-8b2f-02052bb6cbec.png?v=1709898956","url":"https:\/\/afsbio.com\/products\/mcm7-polyclonal-antibody-e-ab-40231","provider":"AFSBio Inc.","version":"1.0","type":"link"}