{"product_id":"mcoln2-polyclonal-antibody-bs67768","title":"MCOLN2 Polyclonal Antibody-BS67768","description":"MCOLN2 Polyclonal Antibody\n\nCatalogue Numbers: BS67768-50, BS67768-100\n\nSizes: 50µl, 100µl\n\nProduct: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.\n\nSwiss-Prot: Q8IZK6\n\nHost: Rabbit\n\nReactivity: Human, Rat\n\nApplications: WB\n\nAll Applications: WB (1\/500 - 1\/1000)\n\nBackground: The mucolipins are a family of cation channel proteins designated mucolipin 1, mucolipin 2 and mucolipin 3. Mucolipin 2 is a lysosomal protein that interacts with the ARF6-associated pathway through co-localization with the cargo proteins CD59 and MHC1. These interactions are thought to traffic and regulate the sorting of certain glycosyl-anchored proteins in the ARF6-associated pathway. Mucolipin 2 is found primarily in the plasma membrane, but is also expressed in intracellular vesicles, tubular structures and B lymphocytes. Mucolipin 2 expression in B lymphocytes and its association with Bruton’s tyrosine kinase suggests a possible role in B lymphocyte development. Additionally, defects in the mucolipin 2 gene may be associated with certain neurosensory disorders, as well as swelling of late endosomes and lysosomes.\n\nPurification and Purity: The antibody was purified by immunogen affinity chromatography.\n\nStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\n\nSpecificity: Recognizes endogenous levels of MCOLN2 protein.\n\nExtra Notes: Western blot analysis of MCOLN2 expression in THP1 (A) whole cell lysates.\n\nBioworld Molecular Weight: ~ 80 kDa\n\nNote: For research use only, not for use in diagnostic procedure.\n\nAlternative Name: Mucolipin-2\n\nImmunogen: Recombinant protein corresponding to human MCOLN2. The exact sequence is proprietary.\n\nConjugate: Unconjugated\n\nModification: Unmodified","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42906358120627,"sku":"BS67768-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42906358153395,"sku":"BS67768-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_ac2bd81c-fc26-400d-b6e3-1c6892697b17.jpg?v=1702918610","url":"https:\/\/afsbio.com\/products\/mcoln2-polyclonal-antibody-bs67768","provider":"AFSBio Inc.","version":"1.0","type":"link"}