{"product_id":"mcr-polyclonal-antibody-bt-ap11186","title":"MCR Polyclonal Antibody - BT-AP11186","description":"\u003cp\u003eMCR Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP11186-20, BT-AP11186-50, BT-AP11186-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cardiovascular; Epigenetics and nuclear signaling; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: NR3C2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Mineralocorticoid receptor\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P08235; Mouse: Q8VII8; Rat: P22199\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Mineralocorticoid receptor;MR;Nuclear receptor subfamily 3 group C member 2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 4306\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239218340019,"sku":"BT-AP11186-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239218372787,"sku":"BT-AP11186-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239218405555,"sku":"BT-AP11186-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_65b847c8-5662-452f-81ff-471398c8ecd9.png?v=1769390734","url":"https:\/\/afsbio.com\/products\/mcr-polyclonal-antibody-bt-ap11186","provider":"AFSBio Inc.","version":"1.0","type":"link"}