{"product_id":"mdhc-polyclonal-antibody-bt-ap11198","title":"MDHC Polyclonal Antibody - BT-AP11198","description":"\u003cp\u003eMDHC Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP11198-20, BT-AP11198-50, BT-AP11198-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes an enzyme that catalyzes the NAD\/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cancer; Metabolism; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MDH1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Malate dehydrogenase, cytoplasmic\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P40925; Mouse: P14152; Rat: O88989\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Malate dehydrogenase, cytoplasmic;EC 1.1.1.37;Cytosolic malate dehydrogenase;Diiodophenylpyruvate reductase;EC 1.1.1.96\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 4190\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239218831539,"sku":"BT-AP11198-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239218864307,"sku":"BT-AP11198-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239218897075,"sku":"BT-AP11198-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_170dd637-b9c1-4933-99f2-4ecfa7009e62.png?v=1769390740","url":"https:\/\/afsbio.com\/products\/mdhc-polyclonal-antibody-bt-ap11198","provider":"AFSBio Inc.","version":"1.0","type":"link"}