{"product_id":"mdm2-monoclonal-antibody-bt-mca2408","title":"MDM2 Monoclonal Antibody - BT-MCA2408","description":"\u003cp\u003eMDM2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2408-50, BT-MCA2408-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MDM2\u003c\/p\u003e\n\n\u003cp\u003eApplications: FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 6B12D2\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: MDM2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide of human MDM2 (AA: cSRPSTSSRRRAISE).\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 55.2kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q00987\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: DMX, hdm2, ACTFS\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 4193\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238554722483,"sku":"BT-MCA2408-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238554755251,"sku":"BT-MCA2408-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_45b75145-0e66-4358-9fd9-bf263cae5f1b.png?v=1769382509","url":"https:\/\/afsbio.com\/products\/mdm2-monoclonal-antibody-bt-mca2408","provider":"AFSBio Inc.","version":"1.0","type":"link"}