{"product_id":"mdm2-monoclonal-antibody-bt-mca4700","title":"MDM2 Monoclonal Antibody - BT-MCA4700","description":"\u003cp\u003eMDM2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4700-50, BT-MCA4700-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MDM2\u003c\/p\u003e\n\n\u003cp\u003eApplications: FCM\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 4A8D12\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: MDM2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human MDM2 (AA: 26-169) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 55.2kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q00987\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: HDMX, LSKB, hdm2, ACTFS\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 4193\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238402449587,"sku":"BT-MCA4700-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238402482355,"sku":"BT-MCA4700-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_0edc832f-f288-43e2-97b8-67a665b51df2.png?v=1769380069","url":"https:\/\/afsbio.com\/products\/mdm2-monoclonal-antibody-bt-mca4700","provider":"AFSBio Inc.","version":"1.0","type":"link"}