{"product_id":"mek-4-k350-polyclonal-antibody-bs2276","title":"MEK-4 (K350) Polyclonal Antibody - BS2276","description":"\u003cp\u003eMEK-4 (K350) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS2276-50, BS2276-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regμlatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK 5, whereas MEK-6 phosphorylates p38 and p38β. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF, IP\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Dual specificity mitogen-activated protein kinase kinase 4, MAP kinase kinase 4, MAPKK 4, JNK-activating kinase 1, MAPK\/ERK kinase 4, MEK 4, SAPK\/ERK kinase 1, SEK1, Stress-activated protein kinase kinase 1, SAPK kinase 1, SAPKK-1, SAPKK1, c-Jun N-terminal kinase kinase 1, JNKK, MAP2K4, JNKK1, MEK4, MKK4, , PRKMK4, SEK1, SERK1, SKK1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 330-380 of Human MEK-4.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:500~1:1000\u003cbr\u003e\nIHC\/IF: 1:50~1:200\u003cbr\u003e\nIP: 1:10~1:100\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Western blot (WB) analysis of MEK-4 (K350) polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane1:Hela whole cell lysate(40ug)\u003cbr\u003e\nLane2:A549 whole cell lysate(40ug)\u003cbr\u003e\nLane3:AML-12 whole cell lysate(40ug)\u003cbr\u003e\nLane4:PC12 whole cell lysate(40ug)\u003cbr\u003e\nLane5:HEK293T whole cell lysate(40ug)\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 44 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: SAPK JNK Signaling Cascades, Signaling Pathways Activating p38 MAP KinaseMAPK Erk in Growth and Differentiation Pathway,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P45985\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946242203827,"sku":"BS2276-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946242236595,"sku":"BS2276-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/mek-4-k350-polyclonal-antibody-bs2276","provider":"AFSBio Inc.","version":"1.0","type":"link"}