{"product_id":"mek-7-phospho-s271-polyclonal-antibody-bs4906","title":"MEK-7  (phospho-S271)  Polyclonal Antibody - BS4906","description":"\u003cp\u003eMEK-7  (phospho-S271)  Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS4906-50, BS4906-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: MKK7 is a MAP kinase kinase that serves as a specific activator of the SAPK\/JNK pathway. MKK7 is strongly activated by TNF-α, as well as other environmental stresses, whereas SEK1\/MKK4, which activates both p38 and SAPK\/JNK pathways, is not activated by TNF-α. Sequence alignment of the activation loop of the MAP kinase kinase family members indicates that Ser271 and Thr275 are potential phosphorylation sites that are crucial for the kinase acivity.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Mitogen Activated Protein Kinase kinase 7, c-Jun N-terminal kinase kinase 2, JNK activating kinase 2, Jnkk 2, Jnkk2, MAP2K7, MAPKK-7, MKK 7, MKK-7, PRKMK 7, PRKMK7, Sek-2, Dual specificity mitogen activated protein kinase kinase 7, JNK kinase 2, Jnkk\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic phosphopeptide derived from human MEK-7 around the phosphorylation site of Serine 271\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: MEK-7 (phospho-S271) polyclonal antibody detects endogenous levels of MEK-7 protein only when phosphorylated at Ser271.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 48 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: SAPK JNK Signaling Cascades,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: O14733\u003c\/p\u003e\n\n\u003cp\u003eProduct: 1 mg\/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946322059443,"sku":"BS4906-50","price":289.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946322092211,"sku":"BS4906-100","price":492.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/mek-7-phospho-s271-polyclonal-antibody-bs4906","provider":"AFSBio Inc.","version":"1.0","type":"link"}