{"product_id":"mek-kinase-1-polyclonal-antibody-bt-ap05333","title":"MEK Kinase-1 Polyclonal Antibody - BT-AP05333","description":"\u003cp\u003eMEK Kinase-1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP05333-20, BT-AP05333-50, BT-AP05333-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by MAP3K1 (mitogen-activated protein kinase kinase kinase 1) is a serine\/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MAP3K1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: MEK Kinase-1 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 161289\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q13233; Mouse: P53349; Rat: Q62925\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: mitogen-activated protein kinase kinase kinase 1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 4214\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239686594739,"sku":"BT-AP05333-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239686627507,"sku":"BT-AP05333-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239686660275,"sku":"BT-AP05333-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_315aa56b-fa41-44f6-ba16-0230854d61bd.png?v=1769398000","url":"https:\/\/afsbio.com\/products\/mek-kinase-1-polyclonal-antibody-bt-ap05333","provider":"AFSBio Inc.","version":"1.0","type":"link"}