{"product_id":"mek3-rabbit-polyclonal-antibody-ra27165","title":"MEK3 Rabbit Polyclonal Antibody - RA27165","description":"\u003cp\u003eMEK3 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA27165-50, RA27165-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: mitogen-activated protein kinase kinase 3 (MAP2K3) Homo sapiens The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14\/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: IHC-p 1:50-300\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3;MAPKK 3;EC 2.7.12.2;MAPK\/ERK kinase 3;MEK 3;Stress-activated protein kinase kinase 2;SAPK kinase 2;SAPKK-2;SAPKK2)\u003c\/p\u003e \n\n\u003cp\u003eApplications: IHC-p; IF (paraffin section)\u003c\/p\u003e \n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 5606\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 34,39\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P46734\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121393852595,"sku":"RA27165-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121393885363,"sku":"RA27165-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_7cf9f252-569e-4383-80cd-512402c35530.png?v=1773347185","url":"https:\/\/afsbio.com\/products\/mek3-rabbit-polyclonal-antibody-ra27165","provider":"AFSBio Inc.","version":"1.0","type":"link"}