{"product_id":"mel-1b-r-v39-polyclonal-antibody-bs2817","title":"MEL-1B-R (V39) Polyclonal Antibody-BS2817","description":"\u003cp\u003eMEL-1B-R (V39) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers:BS2817-50, BS2817-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P49286\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: IHC: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: The melatonin receptors, MEL-1A-R and MEL-1B-R, are members of the superfamily of guanine nucleotide-binding regulatory protein (G protein)-coupled receptors. The melatonin receptors are activated by the hormone melatonin (Mel), which is secreted by the pineal gland at night as part of the circadian clock. MEL-1A-R, a 37 kD protein, is thought to be involved in pacing the biological clock. However, both MEL-1A-R and MEL-1B-R are implicated in controlling cellular growth in response to melatonin. MEL-1B-R is an integral membrane protein expressed in retina and less in brain and hippocampus. Functional studies of NIH\/3T3 cells stably expressing the MEL-1B-R melatonin receptor indicate that it is coupled to inhibition of adenylyl cyclase.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 40 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: MEL-1B-R (V39) polyclonal antibody detects endogenous levels of MEL-1B-R protein.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003cbr\u003e\nAlternative Name: Melatonin receptor type 1B; Mel-1B-R; Mel1b receptor; MTNR1B\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids N-terminus of Human MEL-1B-R.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42895072821427,"sku":"BS2817-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42895072854195,"sku":"BS2817-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_2e0cd9d9-4e2b-4489-a279-6423e12854ae.jpg?v=1702573279","url":"https:\/\/afsbio.com\/products\/mel-1b-r-v39-polyclonal-antibody-bs2817","provider":"AFSBio Inc.","version":"1.0","type":"link"}