{"product_id":"met-phospho-tyr1235-rabbit-pab-es20169","title":"Met (Phospho Tyr1235) rabbit pAb - ES20169","description":"\u003cp\u003eMet (Phospho Tyr1235) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES20169-50, ES20169-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., disease:Activation of MET after rearrangement with the TPR gene produces an oncogenic protein., disease:Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550]., disease:Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance., disease:Defects in MET may be associated with gastric cancer., disease:Genetic variations in MET may be associated with susceptibility to autism type 9 (AUTS9) [MIM:611015]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior., domain:The kinase domain is involved in SPSB1 binding., function:Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival., online information:C-MET entry, similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family., similarity:Contains 1 protein kinase domain., similarity:Contains 1 Sema domain., similarity:Contains 3 IPT\/TIG domains., subunit:Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D\/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1\/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: Hepatocyte growth factor receptor (HGF receptor; EC 2.7.10.1; HGF\/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met)\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA; IHC\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human Met (Phospho Tyr1235)\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 140170kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 4233\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P08581\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202428330163,"sku":"ES20169-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202428362931,"sku":"ES20169-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_a53c8af3-986e-4dbf-ba97-5389211ca8de.png?v=1767128998","url":"https:\/\/afsbio.com\/products\/met-phospho-tyr1235-rabbit-pab-es20169","provider":"AFSBio Inc.","version":"1.0","type":"link"}