{"product_id":"metadherin-monoclonal-antibody-bt-mca4538","title":"Metadherin Monoclonal Antibody - BT-MCA4538","description":"\u003cp\u003eMetadherin Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4538-50, BT-MCA4538-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Others\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: Metadherin\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 2F11C3\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Metadherin\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human Metadherin expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 64kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q86UE4\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: 3D3, AEG1, LYRIC, MTDH\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 92140\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238631301299,"sku":"BT-MCA4538-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238631334067,"sku":"BT-MCA4538-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_54390028-d78a-41a7-a97f-fa2bcbc48416.png?v=1769383236","url":"https:\/\/afsbio.com\/products\/metadherin-monoclonal-antibody-bt-mca4538","provider":"AFSBio Inc.","version":"1.0","type":"link"}