{"product_id":"methyl-hp1-gamma-cbx3-h175-rabbit-pab-a18812","title":"Methyl-HP1 gamma\/CBX3-H175 Rabbit pAb - A18812","description":"\u003cp\u003eMethyl-HP1 gamma\/CBX3-H175 Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A18812-20, A18812-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Methylated Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: DB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 21kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: Refer to figures\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein (or fragment) .\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 11335\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q13185\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: HECH; HP1-GAMMA; HP1Hs-gamma; Methyl-HP1 gamma\/CBX3-H175\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: DB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics Nuclear Signaling, Protein phosphorylation.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: CBX3\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189779292339,"sku":"A18812-20","price":179.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189779325107,"sku":"A18812-100","price":515.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_e15fa2e7-2a61-4459-b596-6ff6916976ed.png?v=1766435297","url":"https:\/\/afsbio.com\/products\/methyl-hp1-gamma-cbx3-h175-rabbit-pab-a18812","provider":"AFSBio Inc.","version":"1.0","type":"link"}