{"product_id":"mettl7a-polyclonal-antibody-e-ab-52354","title":"METTL7A Polyclonal Antibody - E-AB-52354","description":"\u003cp\u003eMETTL7A Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-52354-60, E-AB-52354-120, E-AB-52354-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: METTL7A\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: AAM B; AAMB; DKFZP586A0522; MET7A; Methyltransferase like 7A; Methyltransferase-like protein 7A; METTL 7A; METTL7A; METTL7A methlytransferase like 7A; Protein AAM-B; Protein AAMB\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q9H8H3\u003c\/p\u003e\n\n\u003cp\u003eBackground: METTL7A (methyltransferase like 7A), also known as AAM-B, is a 244 amino acid protein that is thought to function as a methyltransferase and is encoded by a gene which maps to chromosome 12. Encoding over 1, 100 genes, chromosome 12 comprises nearly 4.5% of the human genome and is associated with a number of skeletal deformaties, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Chromosome 12 is also home to both a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and a natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Additionally, Trisomy 12p (three copies of the p arm of chromosome 12) leads to facial developmental defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.6 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Fusion protein of human METTL7A\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:30-1:150, ELISA 1:5000-1:10000\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43133461463219,"sku":"E-AB-52354-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43133461495987,"sku":"E-AB-52354-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43133461528755,"sku":"E-AB-52354-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_83952af9-0f38-4aaf-95b4-a19feeff5c7c.png?v=1709899310","url":"https:\/\/afsbio.com\/products\/mettl7a-polyclonal-antibody-e-ab-52354","provider":"AFSBio Inc.","version":"1.0","type":"link"}