{"product_id":"mgmt-polyclonal-antibody-bt-ap05395","title":"MGMT Polyclonal Antibody - BT-AP05395","description":"\u003cp\u003eMGMT Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP05395-20, BT-AP05395-50, BT-AP05395-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. Methylated-DNA--protein-cysteine methyltransferase encoded by MGMT is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. Methylated-DNA--protein-cysteine methyltransferase catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MGMT\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: MGMT Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 21646\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P16455; Mouse: P26187; Rat: P24528\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: MGMT; Methylated-DNA--protein-cysteine methyltransferase; 6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 4255; Rat: 25332\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239691477171,"sku":"BT-AP05395-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239691509939,"sku":"BT-AP05395-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239691542707,"sku":"BT-AP05395-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_492996aa-7466-4a1f-8dec-638e8839479f.png?v=1769398084","url":"https:\/\/afsbio.com\/products\/mgmt-polyclonal-antibody-bt-ap05395","provider":"AFSBio Inc.","version":"1.0","type":"link"}