{"product_id":"mi2-alpha-monoclonal-antibody-bt-mca0885","title":"Mi2- Alpha Monoclonal Antibody - BT-MCA0885","description":"\u003cp\u003eMi2- Alpha Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA0885-50, BT-MCA0885-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase\/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2\/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling; Immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CHD3\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, IF, ICC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human,Mouse,Rat,Bovine,Dog,Pig\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Chromodomain-helicase-DNA-binding protein 3\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q12873\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CHD3; Chromodomain-helicase-DNA-binding protein 3; CHD-3; ATP-dependent helicase CHD3; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; Zinc finger helicase; hZFH\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 1107\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238730850483,"sku":"BT-MCA0885-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238730883251,"sku":"BT-MCA0885-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_f6c5aed0-6cee-420d-ac87-c42728ef4ad5.png?v=1769384189","url":"https:\/\/afsbio.com\/products\/mi2-alpha-monoclonal-antibody-bt-mca0885","provider":"AFSBio Inc.","version":"1.0","type":"link"}