{"product_id":"mia3-polyclonal-antibody-bs76390","title":"MIA3 Polyclonal Antibody-BS76390","description":"\u003cp\u003eMIA3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers:BS76390-50, BS76390-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q5JRA6\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB,1:200 - 1:2000\u003c\/p\u003e\n\n\u003cp\u003eBackground: Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1 secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23\/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum. Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB\/SEC12 to ERES.\u003c\/p\u003e \n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003cbr\u003e\nSpecificity: Unmodification\u003c\/p\u003e \n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003cbr\u003e\nAlternative Name: MIA3;ARNT;D320;TANGO;TANGO1;UNQ6077\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human MIA3(NP_940953.2).\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42895103590579,"sku":"BS76390-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42895103623347,"sku":"BS76390-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_b38f5240-9a4e-4f0e-ace5-108e13212a89.jpg?v=1702573563","url":"https:\/\/afsbio.com\/products\/mia3-polyclonal-antibody-bs76390","provider":"AFSBio Inc.","version":"1.0","type":"link"}