{"product_id":"mkp-2-y108-polyclonal-antibody-bs2302","title":"MKP-2 (Y108) Polyclonal Antibody-BS2302","description":"\u003cp\u003eMKP-2 (Y108) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS2302-50, BS2302-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q13115\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: IHC: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and\/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK\/ERK, SAPK\/JNK and p38. The members of the dual-specificity phosphatase protein family include MKP-1\/CL100 (3CH134), VHR, PAC1, MKP-2, hVH-3 (B23), hVH-5, MKP-3, MKP-X, and MKP- 4. Human MKP-2 maps to chromosome 8p12-p11 and encodes a 394 amino acid, 43 kDa protein that specifically inactivates ERK1, ERK2 and JNK.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Immunohistochemistry (IHC) analyzes of MKP-2 (Y108) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 44 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: MKP-2 (Y108) polyclonal antibody detects endogenous levels of MKP-2 protein.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Dual specificity protein phosphatase 4; Dual specificity protein phosphatase hVH2; Mitogen-activated protein kinase phosphatase 2; MAP kinase phosphatase 2; MKP-2; DUSP4; MKP2; VH2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 80-130 of Human MKP-2.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42939298054323,"sku":"BS2302-50","price":254.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42939298087091,"sku":"BS2302-100","price":442.75,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_fa6fb8af-6ddf-45a1-951d-a67e8db23b14.jpg?v=1704545835","url":"https:\/\/afsbio.com\/products\/mkp-2-y108-polyclonal-antibody-bs2302","provider":"AFSBio Inc.","version":"1.0","type":"link"}