{"product_id":"mkp-4-a174-polyclonal-antibody-bs2348","title":"MKP-4 (A174) Polyclonal Antibody-BS2348","description":"\u003cp\u003eMKP-4 (A174) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS2348-50, BS2348-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q99956\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC, IF\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: IHC: 1:50~1:200\u003cbr\u003e\nIF: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and\/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK\/ERK, SAPK\/JNK and p38. The members of the dual-specificity phosphatase protein family include MKP-1\/CL100 (3CH134), VHR, PAC1, MKP-2, hVH-3 (B23), hVH-5, MKP-3, MKP-X and MKP-4.\u003c\/p\u003e \n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Immunohistochemistry (IHC) analyzes of MKP-4 (A174) pAb in paraffin-embedded liver cancer tissue at 1:100.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 42 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: MKP-4 (A174) polyclonal antibody detects endogenous levels of MKP-4 protein.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Dual specificity protein phosphatase 9; Mitogen-activated protein kinase phosphatase 4; MAP kinase phosphatase 4; MKP-4; DUSP9; MKP4\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 140-184 of Human MKP-4.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42939302346931,"sku":"BS2348-50","price":254.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42939302412467,"sku":"BS2348-100","price":442.75,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_cbb44f5d-0d2b-4e7c-a0d1-8bbdc6caa891.jpg?v=1704545847","url":"https:\/\/afsbio.com\/products\/mkp-4-a174-polyclonal-antibody-bs2348","provider":"AFSBio Inc.","version":"1.0","type":"link"}