{"product_id":"mlh1-monoclonal-antibody-bt-mca3764","title":"MLH1 Monoclonal Antibody - BT-MCA3764","description":"\u003cp\u003eMLH1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA3764-50, BT-MCA3764-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MLH1\u003c\/p\u003e\n\n\u003cp\u003eApplications: ICC, FCM\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 8C12B7\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG2b\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: MLH1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human MLH1 (AA: 381-483) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 84.6kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P40692\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: FCC2, COCA2, HNPCC, hMLH1, HNPCC2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 4292\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238410117299,"sku":"BT-MCA3764-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238410150067,"sku":"BT-MCA3764-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_77b9a624-8a33-4211-a5b0-210cea208f57.png?v=1769380230","url":"https:\/\/afsbio.com\/products\/mlh1-monoclonal-antibody-bt-mca3764","provider":"AFSBio Inc.","version":"1.0","type":"link"}