{"product_id":"mlh1-monoclonal-antibody-bt-mca4592","title":"MLH1 Monoclonal Antibody - BT-MCA4592","description":"\u003cp\u003eMLH1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4592-50, BT-MCA4592-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: DNA-mismatch repair (MMR), a conserved process that involves correcting errors made during DNA synthesis, is crucial to the maintenance of genomic integrity. Lack of a functional DNA-mismatch repair pathway is a common characteristic of several different types of human cancers, either due to an MMR gene mutation or promoter-methylation gene silencing. MLH1 is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in hereditary nonpolyposis colon cancer (HNPCC). MLH1 is an integral part of the protein complex responsible for mismatch repair expressed in lymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid and gall bladder, and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectal cancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Inactivation of the MLH1 gene causes genome instability and predisposition to cancer. MLH1 also plays a role in meiotic recombination.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MLH1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, ICC\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Monkey\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 4C9C7\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: MLH1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of MLH1 (aa381-483) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 85kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P40692\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: FCC2, COCA2, HNPCC\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 4292\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238646276275,"sku":"BT-MCA4592-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238646309043,"sku":"BT-MCA4592-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_ffa65d31-0fd1-47d3-8ff5-656747429156.png?v=1769383376","url":"https:\/\/afsbio.com\/products\/mlh1-monoclonal-antibody-bt-mca4592","provider":"AFSBio Inc.","version":"1.0","type":"link"}