{"product_id":"mlh1-polyclonal-antibody-bt-ap05452","title":"MLH1 Polyclonal Antibody - BT-AP05452","description":"\u003cp\u003eMLH1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP05452-20, BT-AP05452-50, BT-AP05452-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: MLH1 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E.coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MLH1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: MLH1 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 84601\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P40692; Mouse: Q9JK91; Rat: P97679\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: MLH1; COCA2; DNA mismatch repair protein Mlh1; MutL protein homolog 1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 4292; Mouse: 17350; Rat: 81685\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239695016115,"sku":"BT-AP05452-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239695048883,"sku":"BT-AP05452-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239695081651,"sku":"BT-AP05452-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_6ad16bac-6b09-4a18-bf1f-9493224e3777.png?v=1769398142","url":"https:\/\/afsbio.com\/products\/mlh1-polyclonal-antibody-bt-ap05452","provider":"AFSBio Inc.","version":"1.0","type":"link"}