{"product_id":"mlk1-2-phospho-thr312-266-rabbit-pab-es6249","title":"MLK1\/2 (phospho Thr312\/266) rabbit pAb - ES6249","description":"\u003cp\u003eMLK1\/2 (phospho Thr312\/266) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES6249-50, ES6249-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation., function:Activates the JUN N-terminal pathway., PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site., similarity:Belongs to the protein kinase superfamily. STE Ser\/Thr protein kinase family. MAP kinase kinase kinase subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 1 SH3 domain., subunit:Homodimer., tissue specificity:Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: MAP3K9; MLK1; PRKE1; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; MAP3K10; MLK2; MST; Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; Protein kinase MST\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/5000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human MLK1\/2 around the phosphorylation site of Thr312\/266. AA range:281-330\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 4293\/4294\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P80192\/Q02779\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: intracellular, integral component of membrane,\u003c\/p\u003e \n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45201833197747,"sku":"ES6249-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45201833230515,"sku":"ES6249-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_c5bb4a6f-d064-4f00-a8bf-683aa8ac372c.png?v=1767112841","url":"https:\/\/afsbio.com\/products\/mlk1-2-phospho-thr312-266-rabbit-pab-es6249","provider":"AFSBio Inc.","version":"1.0","type":"link"}