{"product_id":"mlk4-rabbit-polyclonal-antibody-es2799","title":"MLK4 Rabbit Polyclonal Antibody - ES2799","description":"\u003cp\u003eMLK4 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES2799-50, ES2799-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.,function:Activates the JUN N-terminal pathway.,PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.,similarity:Belongs to the protein kinase superfamily. STE Ser\/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH3 domain.,subunit:Homodimer.,\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse,\u003c\/p\u003e \n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA, IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: MLK4, KIAA1804, Mitogen-activated protein kinase kinase kinase MLK4, Mixed lineage kinase 4\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human MAP3KL4. AA range:631-680\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: MLK4\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: MLK4 Polyclonal Antibody detects endogenous levels of MLK4 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Brain, Heart,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 110kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: ATP + a protein = ADP + a phosphoprotein\u003cbr\u003e\nCofactor: Magnesium\u003cbr\u003e\nEnzyme Regulation: Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation\u003cbr\u003e\nFunction: Activates the JUN N-terminal pathway\u003cbr\u003e\nPTM: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation\u003cbr\u003e\nSimilarity: Belongs to the protein kinase superfamily. STE Ser\/Thr protein kinase family. MAP kinase kinase kinase subfamily\u003cbr\u003e\nSimilarity: Contains 1 protein kinase domain\u003cbr\u003e\nSimilarity: Contains 1 SH3 domain\u003cbr\u003e\nSubunit: Homodimer\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: intracellular,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: MLK4\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Mitogen-activated protein kinase kinase kinase MLK4\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q8VDG6\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314230841523,"sku":"ES2799-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314230874291,"sku":"ES2799-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/mlk4-rabbit-polyclonal-antibody-es2799","provider":"AFSBio Inc.","version":"1.0","type":"link"}