{"product_id":"mlkl-8h7-mouse-mab-em1328","title":"MLKL (8H7) Mouse mAb - EM1328","description":"\u003cp\u003eMLKL (8H7) Mouse mAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: EM1328-50, EM1328-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase that was identified as downstream target of RIP3 in the necroptosis pathway. During necroptosis RIP3 is phosphorylated at Ser227, which recruits MLKL and leads to its phosphorylation at Thr357 and Ser358.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Name: Mixed lineage kinase domain like protein, FLJ34389\u003c\/p\u003e\n\n\u003cp\u003eSource: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:100-200\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic Peptide\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG1\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 54kDa\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 197259\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q8NB16\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell membrane,  Cytoplasm,  Membrane\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45201995071667,"sku":"EM1328-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45201995104435,"sku":"EM1328-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_3909cde7-4fb8-4ce2-b612-2b7b21d362e7.png?v=1767119561","url":"https:\/\/afsbio.com\/products\/mlkl-8h7-mouse-mab-em1328","provider":"AFSBio Inc.","version":"1.0","type":"link"}