{"product_id":"mlkl-mouse-monoclonal-antibody-8h7-ra11670","title":"MLKL Mouse Monoclonal Antibody (8H7) - RA11670","description":"\u003cp\u003eMLKL Mouse Monoclonal Antibody (8H7)\u003c\/p\u003e \n\n\u003cp\u003eSize: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA11670-50, RA11670-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: mixed lineage kinase domain like (MLKL) Homo sapiens This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p; IF (paraffin section)\u003c\/p\u003e \n\n\u003cp\u003eSpecies Cross-Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 197259\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 54\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q8NB16\u003c\/p\u003e\n\n\u003cp\u003eSource: Mouse\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45119045533875,"sku":"RA11670-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45119045566643,"sku":"RA11670-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_0a19699b-d8a6-43e9-8e38-453d7406969a.png?v=1773344561","url":"https:\/\/afsbio.com\/products\/mlkl-mouse-monoclonal-antibody-8h7-ra11670","provider":"AFSBio Inc.","version":"1.0","type":"link"}