{"product_id":"mltk-polyclonal-antibody-bt-ap05467","title":"MLTK Polyclonal Antibody - BT-AP05467","description":"\u003cp\u003eMLTK Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP05467-20, BT-AP05467-50, BT-AP05467-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: MLTK is a member of the MAPKKK family of signal transduction molecules and encodes a protein, Mitogen-activated protein kinase kinase kinase MLT, with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MLTK\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: MLTK Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 91181\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9NYL2; Mouse: Q9ESL4\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: MLTK; ZAK; HCCS4; Mitogen-activated protein kinase kinase kinase MLT; Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitog\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 51776; Mouse: 65964\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239696031923,"sku":"BT-AP05467-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239696064691,"sku":"BT-AP05467-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239696097459,"sku":"BT-AP05467-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_f5ea3a1c-ca78-4b1b-8423-2b2f49ccab15.png?v=1769398156","url":"https:\/\/afsbio.com\/products\/mltk-polyclonal-antibody-bt-ap05467","provider":"AFSBio Inc.","version":"1.0","type":"link"}