{"product_id":"mmp-11-polyclonal-antibody-bs90867","title":"MMP-11 Polyclonal Antibody-BS90867","description":"\u003cp\u003eMMP-11 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS90867-50, BS90867-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P24347(Human) Q02853(Mouse) Q499S5(Rat)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC\/IF, IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:1,000\u003cbr\u003e\nICC:1:500-1:1,000\u003cbr\u003e\nIHC:1:100-1:500\u003c\/p\u003e\n\n\u003cp\u003eBackground: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including Collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also called stromelysin-1, -2 and -3) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: MMP-11 polyclonal antibody detects endogenous levels of MMP-11 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 55 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of MMP11 on mouse spleen lysates using anti-MMP11 antibody at 1\/1,000 dilution., ICC staining MMP11 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100\/PBS.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: SL-3, ST3, MMP-11, MMP11, Matrix Metalloproteinase 11, Matrix metalloproteinase-11, MMP-11, Mmp11, MMP11, SL 3, SL-3, SL3, ST3, STMY3, Stromelysin 3, Stromelysin III, Stromelysin-3,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: recombinant protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42984594473139,"sku":"BS90867-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42984594505907,"sku":"BS90867-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_b6521819-4eaa-42b8-8912-ab4e87609ea3.jpg?v=1705918982","url":"https:\/\/afsbio.com\/products\/mmp-11-polyclonal-antibody-bs90867","provider":"AFSBio Inc.","version":"1.0","type":"link"}