{"product_id":"mmp25-polyclonal-antibody-bt-ap11406","title":"MMP25 Polyclonal Antibody - BT-AP11406","description":"\u003cp\u003eMMP25 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP11406-20, BT-AP11406-50, BT-AP11406-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer; Cell biology; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MMP25\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Matrix metalloproteinase-25\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9NPA2; Mouse: Q3U435\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Matrix metalloproteinase-25;MMP-25;EC 3.4.24.-;Leukolysin;Membrane-type matrix metalloproteinase 6;MT-MMP 6;MTMMP6;Membrane-type-6 matrix metalloproteinase;MT6-MMP;MT6MMP\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 64386\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239224467635,"sku":"BT-AP11406-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239224500403,"sku":"BT-AP11406-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239224533171,"sku":"BT-AP11406-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_d8cb8e91-fd88-4404-9033-422a7bd17dd6.png?v=1769390823","url":"https:\/\/afsbio.com\/products\/mmp25-polyclonal-antibody-bt-ap11406","provider":"AFSBio Inc.","version":"1.0","type":"link"}