{"product_id":"mmp8-polyclonal-antibody-e-ab-15777","title":"MMP8 Polyclonal Antibody - E-AB-15777","description":"\u003cp\u003eMMP8 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-15777-60, E-AB-15777-120, E-AB-15777-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: MMP8\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CLG 1; CLG1; Collagenase 1; Collagenase 1 neutrophil; HNC; Matrix metallopeptidase 8 (neutrophil collagenase); Matrix metalloprotease 8; Matrix metalloproteinase-8; MMP 8; MMP-8; Mmp8; MMP8; Neutrophil collagenase; PMNL CL; PMNL collagenase; PMNL-CL; PMNLCL\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Cardiovascular, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P22894\u003c\/p\u003e\n\n\u003cp\u003eBackground: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.4 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide of human MMP8\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IHC 1:25-1:100\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 53kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43143817101491,"sku":"E-AB-15777-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43143817134259,"sku":"E-AB-15777-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43143817167027,"sku":"E-AB-15777-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_7ed0ff4a-1536-4583-af7f-4b520946fd56.png?v=1710241972","url":"https:\/\/afsbio.com\/products\/mmp8-polyclonal-antibody-e-ab-15777","provider":"AFSBio Inc.","version":"1.0","type":"link"}