{"product_id":"mnk2-rabbit-pab-es5625","title":"Mnk2 rabbit pAb - ES5625","description":"\u003cp\u003eMnk2 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES5625-50, ES5625-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: MAP kinase interacting serine\/threonine kinase 2 (MKNK2) Homo sapiens This gene encodes a member of the calcium\/calmodulin-dependent protein kinases (CAMK) Ser\/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC (VHL) ubiquitin ligase E3 complex.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Name: MKNK2; GPRK7; MNK2; MAP kinase-interacting serine\/threonine-protein kinase 2; MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA; IHC\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from the Internal region of human Mnk2.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 51kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 2872\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q9HBH9\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: [Isoform 2]: Nucleus, PML body.; [Isoform 1]: Cytoplasm.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202258362547,"sku":"ES5625-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202258395315,"sku":"ES5625-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_da3f5b84-a5fe-456e-b6ea-584d7abde2bd.png?v=1767125254","url":"https:\/\/afsbio.com\/products\/mnk2-rabbit-pab-es5625","provider":"AFSBio Inc.","version":"1.0","type":"link"}