{"product_id":"mobp-polyclonal-antibody-bs65670","title":"MOBP Polyclonal Antibody-BS65670","description":"\u003cp\u003eMOBP Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS65670-50, BS65670-100\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q13875\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eMOBP Polyclonal Antibody-BS65670\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-P\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: IHC-P=1:100-500\u003c\/p\u003e\n\n\u003cp\u003eBackground: The gene encoding MOBP a member of the central nervous system myelin-constituting proteins, maps to chromosome 3p22.2. MOBP has many splice variants that share a 68 amino acid N-terminal domain. MOBP-71, MOBP-81A, MOBP-99, and MOBP-169 are MOBP splice variants that contain exon 8b, which is similar to myelin basic protein (MBP) mRNA RTS, however MOBP-69, MOBP-81B, and MOBP-170 lack this exon. The splice variants that contain exon 8b are expressed in myelin, while those lacking exon 8b are retained in the oligodendrocyte soma. Exon 8b-containing variants are directed to sites of myelin sheath assembly by exon 8b, where they play a structural role in myelin formation. Splice variants lacking exon 8b likely play a cellular and\/or regulatory role. MOBP is implicated in multiple sclerosis (MS), a human demyelinating disease, and in allergic encephalomyelitis in rodents.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: affinity purified by Protein A\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: MOBP Polyclonal Antibody detects endogenous levels of MOBP protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 21kD\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Positive sample：Paraformaldehyde-fixed, paraffin embedded (mouse brian)Negative sample：Paraformaldehyde-fixed, paraffin embedded (rat liver)Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MOBP) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C, Positive sample：Paraformaldehyde-fixed, paraffin embedded (rat brian)Negative sample：Paraformaldehyde-fixed, paraffin embedded (rat liver)Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MOBP) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: MGC87379; Myelin associated oligodendrocyte basic protein; MOBP_HUMAN.\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH conjugated synthetic peptide derived from human MOBP\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42962756599987,"sku":"BS65670-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42962756665523,"sku":"BS65670-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_c7efb641-9923-4f87-b939-1bf526b491ed.jpg?v=1705318760","url":"https:\/\/afsbio.com\/products\/mobp-polyclonal-antibody-bs65670","provider":"AFSBio Inc.","version":"1.0","type":"link"}