{"product_id":"monomethyl-histone-h3-k27-rabbit-pab-a2361","title":"MonoMethyl-Histone H3-K27 Rabbit pAb - A2361","description":"\u003cp\u003eMonoMethyl-Histone H3-K27 Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A2361-20, A2361-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4) . The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Methylated Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, DB, IHC-P, IF\/ICC, ELISA, ChIP\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human, Mouse, Rat, Other (Wide Range Predicted)\u003c\/p\u003e \n\n\u003cp\u003eProtein Weight: 15kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 17kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide .\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 8290\/8350\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q16695\/P68431\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: H3\/A; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3FA; H3C10; H3C11; H3C12; HIST1H3A; MonoMethyl-Histone H3-K27\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:500 - 1:1000 DB, 1:500 - 1:2000 IHC-P, 1:50 - 1:200 IF\/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements. ChIP, 5μg antibody for 5μg-10μg of Chromatin\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Protein phosphorylation, Signal Transduction, MAPK-Erk Signaling Pathway, Cell Biology Developmental Biology, Cell Cycle, Immunology Inflammation, NF-kB Signaling Pathway.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: H3C1\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189844533427,"sku":"A2361-20","price":179.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189844566195,"sku":"A2361-100","price":515.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_d2349bd5-4ba2-4b0c-b9e1-915d5eab5cd2.png?v=1766436611","url":"https:\/\/afsbio.com\/products\/monomethyl-histone-h3-k27-rabbit-pab-a2361","provider":"AFSBio Inc.","version":"1.0","type":"link"}