{"product_id":"mouse-monoclonal-antibody-to-human-cdnf-301-100","title":"Mouse Monoclonal Antibody to Human CDNF - 301-100","description":"\u003cp\u003eMouse Monoclonal Antibody to Human CDNF\u003c\/p\u003e\n\n\u003cp\u003eSize: 100 µg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: 301-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Human CDNF\u003c\/p\u003e\n\n\u003cp\u003eImmunogen Description: Recombinant human CDNF protein produced using CHO-based Icosagen Cell factory Ltd. proprietary suspension cell line. Purified from cell culture supernatant\u003c\/p\u003e\n\n\u003cp\u003eBackground: CDNF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- (Lindholm et al. 20007; Voutilainen et al., 2011) and MPTP-induced degeneration (Airavaara et al., 2012) of dopamine neurons in rodent models of Parkinson’s disease. When administered after 6-OHDA or MPTP –lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta\u003c\/p\u003e\n\n\u003cp\u003eUniProt ID: Q49AH0\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: ARMETL1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Mouse monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone: 7D6\u003c\/p\u003e\n\n\u003cp\u003eClass: IgG1\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, mouse; others not tested Binds to the N-terminal part of the human CDNF (aa 25-125)\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA, WB, IF\u003c\/p\u003e\n\n\u003cp\u003eProtocol: ELISA (rhCDNF) 0.1 to 0.2 µg\/ml; ELISA (rmCDNF) 0.13 to 0.4 µg\/ml; WB 0.25 to 1 µg\/ml; IF 0.33 to 10 µg\/ml; \u003cbr\u003e\nMonoclonal antibody working dilution has to be established practically for each particular antigen and assay format\u003c\/p\u003e\n\n\u003cp\u003ePurification: Protein G purification\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS pH 7.4, with 0.1% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is shipped in non-frozen liquid form in ambient conditions\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 °C to -70 °C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles as product degradation may result\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Icosagen","offers":[{"title":"Default Title","offer_id":44502416228531,"sku":"301-100","price":1195.35,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Icosagen_3343b5ad-957d-4207-9f23-636bf7b0baad.png?v=1741969713","url":"https:\/\/afsbio.com\/products\/mouse-monoclonal-antibody-to-human-cdnf-301-100","provider":"AFSBio Inc.","version":"1.0","type":"link"}