{"product_id":"mouse-monoclonal-antibody-to-human-cdnf-302-100","title":"Mouse Monoclonal Antibody to Human CDNF - 302-100","description":"\u003cp\u003eMouse Monoclonal Antibody to Human CDNF\u003c\/p\u003e\n\n\u003cp\u003eSize: 100 µg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: 302-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Human CDNF\u003c\/p\u003e\n\n\u003cp\u003eImmunogen Description: Recombinant human CDNF protein produced using CHO-based Icosagen Cell factory Ltd. proprietary suspension cell line. Purified from cell culture supernatant\u003c\/p\u003e\n\n\u003cp\u003eBackground: CDNF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- (Lindholm et al. 20007; Voutilainen et al., 2011) and MPTP-induced degeneration (Airavaara et al., 2012) of dopamine neurons in rodent models of Parkinson’s disease. When administered after 6-OHDA or MPTP –lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta\u003c\/p\u003e\n\n\u003cp\u003eUniProt ID: Q49AH0\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: ARMETL1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Mouse monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone: 6G5\u003c\/p\u003e\n\n\u003cp\u003eClass: IgG1\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, no reactivity with mouse CDNF Binds to the C-terminal part of the human CDNF (aa 126-187)\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA, WB, IF, IHC\u003c\/p\u003e\n\n\u003cp\u003eProtocol: ELISA - 0.06 to 0.2 µg\/ml; WB - 0.25 to 1 µg\/ml; IF - 0.3 to 10 µg\/ml; IHC (on formalin-fixed, paraffin-embedded tissues, antigen retrieval) - 5 to 10 µg\/ml; \u003cbr\u003e\nMonoclonal antibody working titer has to be established practically for each particular antigen and assay format\u003c\/p\u003e\n\n\u003cp\u003ePurification: Protein G purified\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS pH 7.4, with 0.1% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is shipped in non-frozen liquid form in ambient conditions\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at – 20 or -70 °C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles as product degradation may result.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Icosagen","offers":[{"title":"Default Title","offer_id":44502416294067,"sku":"302-100","price":1195.35,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Icosagen_ca7d35c6-6f12-40c6-92de-a21388b14154.png?v=1741969715","url":"https:\/\/afsbio.com\/products\/mouse-monoclonal-antibody-to-human-cdnf-302-100","provider":"AFSBio Inc.","version":"1.0","type":"link"}