{"product_id":"mouse-monoclonal-antibody-to-human-manf-mesencephalic-astrocyte-derived-neurotrophic-factor-311-100","title":"Mouse Monoclonal Antibody to Human MANF\n (Mesencephalic Astrocyte-Derived Neurotrophic Factor) - 311-100","description":"\u003cp\u003eMouse Monoclonal Antibody to Human MANF\u003cbr\u003e\n (Mesencephalic Astrocyte-Derived Neurotrophic Factor)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100 µg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: 311-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Human MANF\u003c\/p\u003e\n\n\u003cp\u003eImmunogen Description: Recombinant human MANF protein produced using CHO-based Icosagen Cell factory Ltd. proprietary suspension cell line. Immunogen is purified from cell culture supernatant\u003c\/p\u003e\n\n\u003cp\u003eBackground: MANF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- induced degeneration of dopamine neurons in rodent models of Parkinson’s disease (Lindholm et al., 2008, Voutilainen et al., 2009). When administered after 6-OHDA-lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta\u003c\/p\u003e\n\n\u003cp\u003eUniProt ID: P55145\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: ARMET, ARP\u003c\/p\u003e\n\n\u003cp\u003eClonality: Mouse monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone: 1G12\u003c\/p\u003e\n\n\u003cp\u003eClass: IgG1\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human MANF\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA, WB, IF\u003c\/p\u003e\n\n\u003cp\u003eProtocol: ELISA 0.1 to 0.2 µg\/ml; WB 0.5 to 2 µg\/ml; IF 1 to 10 µg\/ml\u003cbr\u003e\nMonoclonal antibody working titer has to be established practically for each particular antigen and assay format\u003c\/p\u003e\n\n\u003cp\u003ePurification: Protein G purification\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS pH 7.4, with 0.1% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is shipped in non-frozen liquid form in ambient conditions\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20°C to -70°C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Icosagen","offers":[{"title":"Default Title","offer_id":44502416359603,"sku":"311-100","price":1195.35,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Icosagen_4238c69a-275b-492d-b736-a95a9ed30f58.png?v=1741969717","url":"https:\/\/afsbio.com\/products\/mouse-monoclonal-antibody-to-human-manf-mesencephalic-astrocyte-derived-neurotrophic-factor-311-100","provider":"AFSBio Inc.","version":"1.0","type":"link"}