{"product_id":"mprd-rabbit-polyclonal-antibody-es9515","title":"MPRD Rabbit Polyclonal Antibody - ES9515","description":"\u003cp\u003eMPRD Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES9515-50, ES9515-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from part region of human protein\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: MPRD\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: MPRD Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Leukocyte, Liver, Muscle, Uterus,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 30kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Lysosome, Phagosome, Salmonella infection\u003c\/p\u003e\n\n\u003cp\u003eFunction: Domain: The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor\u003cbr\u003e\nFunction: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex\u003cbr\u003e\nMiscellaneous: This receptor has optimal binding in the presence of divalent cations\u003cbr\u003e\nSubunit: Homodimer. Binds GGA1, GGA2 and GGA3\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Lysosome membrane, Single-pass type I membrane protein\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: M6PR MPR46 MPRD\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46)\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P24668\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q6AY20\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314137059507,"sku":"ES9515-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314137092275,"sku":"ES9515-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/mprd-rabbit-polyclonal-antibody-es9515","provider":"AFSBio Inc.","version":"1.0","type":"link"}