{"product_id":"mrckg-rabbit-pab-es10590","title":"MRCKG rabbit pAb - ES10590","description":"\u003cp\u003eMRCKG rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES10590-50, ES10590-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation., function:May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation., similarity:Belongs to the protein kinase superfamily. AGC Ser\/Thr protein kinase family. DMPK subfamily., similarity:Contains 1 AGC-kinase C-terminal domain., similarity:Contains 1 CNH domain., similarity:Contains 1 CRIB domain., similarity:Contains 1 PH domain., similarity:Contains 1 phorbol-ester\/DAG-type zinc finger., similarity:Contains 1 protein kinase domain., subcellular location:Concentrates at the leading edge of cells., subunit:Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42., tissue specificity:Expressed in heart and skeletal muscle.,\u003c\/p\u003e \n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat; Mouse;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human protein . at AA range: 1370-1450\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 170kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 55561\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q6DT37\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm. Concentrates at the leading edge of cells.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45201731125427,"sku":"ES10590-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45201731158195,"sku":"ES10590-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_f492b1f0-34e2-4fe0-955e-87e68f7b85b9.png?v=1767110496","url":"https:\/\/afsbio.com\/products\/mrckg-rabbit-pab-es10590","provider":"AFSBio Inc.","version":"1.0","type":"link"}