{"product_id":"mre11-phospho-ser676-rabbit-polyclonal-antibody-bt-ap11362","title":"Mre11 (Phospho-Ser676) Rabbit Polyclonal Antibody - BT-AP11362","description":"\u003cp\u003eMre11 (Phospho-Ser676) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP11362-20, BT-AP11362-50, BT-AP11362-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a nuclear protein involved in homologous recombination| telomere length maintenance| and DNA double-strand break repair. By itself| the protein has 3andapos; to 5andapos; exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3andapos; to 5andapos; exonuclease activities. In conjunction with a DNA ligase| this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MRE11A\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Mre11\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P49959; Mouse: Q61216; Rat: Q9JIM0\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Mre11;Ser676; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 4361; Mouse: 17535; Rat: 64046\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239006396595,"sku":"BT-AP11362-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239006429363,"sku":"BT-AP11362-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239006462131,"sku":"BT-AP11362-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_917bbc64-334a-4e56-9209-39a48b89c79c.png?v=1769387871","url":"https:\/\/afsbio.com\/products\/mre11-phospho-ser676-rabbit-polyclonal-antibody-bt-ap11362","provider":"AFSBio Inc.","version":"1.0","type":"link"}