{"product_id":"mrp5-polyclonal-antibody-bt-ap11536","title":"MRP5 Polyclonal Antibody - BT-AP11536","description":"\u003cp\u003eMRP5 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP11536-20, BT-AP11536-50, BT-AP11536-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR\/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Metabolism; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ABCC5\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Multidrug resistance-associated protein 5\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: O15440; Mouse: Q9R1X5; Rat: Q9QYM0\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Multidrug resistance-associated protein 5;ATP-binding cassette sub-family C member 5;Multi-specific organic anion transporter C;MOAT-C;SMRP;pABC11\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 10057\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239227023539,"sku":"BT-AP11536-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239227056307,"sku":"BT-AP11536-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239227089075,"sku":"BT-AP11536-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_fb8eb404-cda0-4f44-941f-62e75b50e35f.png?v=1769390863","url":"https:\/\/afsbio.com\/products\/mrp5-polyclonal-antibody-bt-ap11536","provider":"AFSBio Inc.","version":"1.0","type":"link"}